Jiawei Zhao

Jun 13, 2024 | science.org | Juhyuk Park |Yang Liu |Jiawei Zhao

AbstractMost insects, including human-targeting mosquitoes, detect odors through odorant-activated ion channel complexes consisting of a divergent odorant-binding subunit (OR) and a conserved co-receptor subunit (Orco). As a basis for understanding how odorants activate these heteromeric receptors, we report here cryo–electron microscopy (cryo-EM) structures of two different heteromeric odorant receptor complexes containing ORs from disease-vector mosquitos Aedes aegypti or Anopheles gambiae.

Apr 10, 2024 | nature.com | Jiawei Zhao |Matthias Elgeti |Tao Che |Brian K. Kobilka

AbstractThe µ-opioid receptor (µOR) is an important target for pain management1 and molecular understanding of drug action on µOR will facilitate the development of better therapeutics. Here we show, using double electron–electron resonance and single-molecule fluorescence resonance energy transfer, how ligand-specific conformational changes of µOR translate into a broad range of intrinsic efficacies at the transducer level.

Oct 29, 2023 | mdpi.com | Huan Wang |Lixin Zhang |Jiawei Zhao

This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticleby, * and School of Mechanical and Electrical Engineering, Shihezi University, Shihezi 832003, China*Author to whom correspondence should be addressed.

Oct 25, 2023 | mdpi.com | Yu Jie Zheng |Lixin Zhang |Xue Hu |Jiawei Zhao

2.5. Hybrid Optimization of BP Neural NetworkBoth the genetic algorithm (GA) and the particle swarm algorithm (PSO) are population intelligence optimization algorithms in the subject of computer intelligence, and they have advantages and disadvantages. As a result, a hybrid GA-PSO method is developed in this research to optimize the BP neural network by including the genetic operators from the GA algorithm into the PSO algorithm.