Julia Majewska

Aug 5, 2024 | nature.com | Julia Majewska |Avi Mayo |Wolfgang Wagner |Ido Amit

AbstractThe accumulation of senescent cells promotes ageing and age-related diseases, but molecular mechanisms that senescent cells use to evade immune clearance and accumulate in tissues remain to be elucidated. Here we report that p16-positive senescent cells upregulate the immune checkpoint protein programmed death-ligand 1 (PD-L1) to accumulate in ageing and chronic inflammation.