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1 week ago | 
mdpi.com | Felix Reuß |Mariette Vreugdenhil |Emanuel Bueechi |Wolfgang Wagner
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by Felix Reuß *, Mariette Vreugdenhil, Emanuel Bueechi and Wolfgang Wagner Department of Geodesy and Geoinformation, Technische Universität Wien, 1040 Vienna, Austria *Author to whom correspondence should be addressed.
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1 month ago | 
nature.com | Wolfgang Wagner
The aging process is influenced by several factors, including the accumulation of mutations and the acquisition of epigenetic alterations throughout life. A recent study by Koch and colleagues demonstrates that these seemingly independent mechanisms interact: somatic mutations affect DNA methylation and epigenetic age predictions.
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Jan 22, 2025 | 
mdpi.com | Claudio Navacchi |Felix Reuß |Wolfgang Wagner
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Aug 5, 2024 | 
nature.com | Julia Majewska |Avi Mayo |Wolfgang Wagner |Ido Amit
AbstractThe accumulation of senescent cells promotes ageing and age-related diseases, but molecular mechanisms that senescent cells use to evade immune clearance and accumulate in tissues remain to be elucidated. Here we report that p16-positive senescent cells upregulate the immune checkpoint protein programmed death-ligand 1 (PD-L1) to accumulate in ageing and chronic inflammation.
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May 25, 2024 | 
mdpi.com | Wolfgang Wagner |Klaus Hünting |Siriwan D. Martens |Mariana Schneider
All articles published by MDPI are made immediately available worldwide under an open access license. No specialpermission is required to reuse all or part of the article published by MDPI, including figures and tables. Forarticles published under an open access Creative Common CC BY license, any part of the article may be reused withoutpermission provided that the original article is clearly cited. For more information, please refer tohttps://www.mdpi.com/openaccess.
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May 21, 2024 | 
tah.de | Wolfgang Wagner
Holzminden. Seit Monaten verlegen verschiedene Bautrupps in der Stadt Holzminden Glasfaserkabel. Straßenzug um Straßenzug geht es voran, bevor im Herbst die Hausanschlüsse folgen sollen. Vor den Pfingsttagen liefen auch auf dem Kiesberg in Holzminden die baulichen Maßnahmen zur Glasfaser-Kabelverlegung weiter. Weiterlesen nach der AnzeigeWeiterlesen nach der AnzeigeGebuddelt wird unter anderem vom Hohen Weg aus kommend im Corveyblick.
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Mar 28, 2024 | 
spectator.clingendael.org | Michal Onderco |Wolfgang Wagner |Alexander Sorg
Why do some people say they are willing to fight for their country while others do not? Of course, answering this (survey) question is a far cry from anyone’s actual willingness to fight and to risk one’s life in battle, and often the true readiness of people to engage in combat remains unclear until a crisis erupts.1Nevertheless, examining the responses to this question in times of peace remains a compelling proxy for understanding potential behaviours.
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Feb 7, 2024 | 
biorxiv.org | Marco Schmidt |Tiago Maié |Wolfgang Wagner
AbstractCancer-associated fibroblasts (CAFs) are critical components of the tumor microenvironment. Several studies demonstrated molecular differences between CAFs and normal tissue-associated fibroblasts (NAFs). In this study, we isolated CAFs and NAFs from liver tumors and analyzed their DNA methylation profiles. A subset of the CAFs exhibited aberrant DNA methylation, which was also reflected on gene expression level.
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Jan 29, 2024 | 
msn.com | Wolfgang Wagner
Microsoft tritt für den Schutz Ihrer Privatsphäre ein. Microsoft und unsere Drittanbieter verwenden Cookies, um Informationen wie eindeutige IDs zu speichern und darauf zuzugreifen, um unsere Dienste und Anzeigen bereitzustellen, zu pflegen und zu verbessern. Wenn Sie zustimmen, personalisieren MSN und Microsoft Bing die angezeigten Inhalte und Anzeigen.
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Jan 17, 2024 | 
biorxiv.org | Wolfgang Wagner |Kira Zeevaert |Ann-Christine Henneke |Catharina Maassen
AbstractSubstrate elasticity may direct cell-fate decisions of stem cells. However, it is largely unclear how matrix stiffness impacts on differentiation of induced pluripotent stem cells (iPSCs) and if this is also reflected by epigenetic modifications.
