Julio Saez-Rodriguez

Nov 6, 2024 | biorxiv.org | Jan D. Lanzer |Jose Blanco |Julio Saez-Rodriguez |Uni Heidelberg

AbstractHeart failure (HF) is characterized by severely reduced cardiac function and tissue remodeling, driven by complex multicellular regulatory processes. Extensive studies have generated molecular profiles at both bulk and single-cell levels; however, systematic integration that describes tissue-wide changes as a function of cell type coordination remains challenging.

Jun 10, 2024 | nature.com | Yuvarani Masarapu |Egle Cekanaviciute |Jakub O. Westholm |Asa Bjorklund |Åsa K. Björklund |Pau Badia-i-Mompel | +11 more

AbstractImpairment of the central nervous system (CNS) poses a significant health risk for astronauts during long-duration space missions. In this study, we employed an innovative approach by integrating single-cell multiomics (transcriptomics and chromatin accessibility) with spatial transcriptomics to elucidate the impact of spaceflight on the mouse brain in female mice.

Feb 12, 2024 | nature.com | Annika Reinke |Minu Tizabi |Michael Baumgartner |A. Emre Kavur |Tim Rädsch |Laura Acion | +36 more

AbstractValidation metrics are key for tracking scientific progress and bridging the current chasm between artificial intelligence research and its translation into practice. However, increasing evidence shows that, particularly in image analysis, metrics are often chosen inadequately.

Feb 12, 2024 | nature.com | Annika Reinke |Minu Tizabi |Michael Baumgartner |A. Emre Kavur |Tim Rädsch |Laura Acion | +36 more

AbstractValidation metrics are key for tracking scientific progress and bridging the current chasm between artificial intelligence research and its translation into practice. However, increasing evidence shows that, particularly in image analysis, metrics are often chosen inadequately.

Nov 24, 2023 | science.org | Qian Bu |Yuki Takada |Manuel F. Ferrer-Garcia |Nadine Kaesler |Aurelien Dugourd |Julio Saez-Rodriguez | +4 more

Mapping cardiac remodeling in chronic kidney diseaseNadine Kaesler https://orcid.org/0000-0001-8097-7660, Mingbo Cheng https://orcid.org/0000-0003-3938-0461, [...] , James Nagai https://orcid.org/0000-0002-7655-7206, James O’Sullivan https://orcid.org/0009-0002-3425-6058, [...] , Fabian Peisker https://orcid.org/0000-0003-0123-8179, Eric M. J.