Jun Qin

2 months ago | cell.com | Mona Teng |Jiacheng Guo |Xin Xu |Xinpei Ci |Yulin Mo |Yakup Kohen | +22 more

Keywords circular RNA noncoding RNA neuroedocrine prostate cancer small cell lung cancer transcription factors RNA protein interactions lineage plasticity Introduction Circular RNA (circRNA) is a class of noncoding RNA (ncRNA) primarily generated by backsplicing.2,3 The circularization can be promoted through the binding of reverse complementary repetitive sequences in the flanking introns or the dimerization of RNA-binding proteins.2,4 Due to the lack of poly(A) tail, circRNA is...

Sep 26, 2024 | nature.com | Ling Yao |Tang Liu |Jun Qin |Hou Jiang |Lin Yang |Peter Smith | +1 more

AbstractChina’s large-scale tree planting programs are critical for achieving its carbon neutrality by 2060, but determining where and how to plant trees for maximum carbon sequestration has not been rigorously assessed. Here, we developed a comprehensive machine learning framework that integrates diverse environmental variables to quantify tree growth suitability and its relationship with tree numbers. Then, their correlations with biomass carbon stocks were robustly established.

Sep 2, 2024 | actaneurocomms.biomedcentral.com | Jun Qin

ReferencesAdnani L, Dixit R, Chen X, Balakrishnan A, Modi H, Touahri Y, Logan C, Schuurmans C (2018) Plag1 and Plagl2 have overlapping and distinct functions in telencephalic development. Biol Open 7(11):bio038661 (PMID: 30361413)Article  PubMed  PubMed Central  Google Scholar  Arabzade A, Zhao Y, Varadharajan S et al (2021) ZFTA-RELA dictates oncogenic transcriptional programs to drive aggressive supratentorial ependymoma.

Jul 26, 2024 | nature.com | Jun Qin

AbstractCastration-resistant prostate cancer (CRPC) nearly inevitably develops after long-term treatment with androgen deprivation therapy (ADT), leading to significant mortality. Investigating the mechanisms driving CRPC development is imperative. Here, we determined that the pioneer transcription factor GATA2, which is frequently amplified in CRPC patients, inhibits interferon (IFN)-β-mediated antitumor immunity, thereby promoting CRPC progression.