Xin Xu

2 weeks ago | elifesciences.org | Elvis Quiroz |Tianyuan Wang |Xin Xu |Lin Evlin

eLife Assessment This valuable study employed a multi-omics approach to elucidate the regulatory mechanism underlying parturition and myometrial quiescence. The data presented to support the main conclusion are solid. This work will be of interest to both basic researchers who work on reproductive biology and clinicians who practice reproductive medicine.

2 weeks ago | dx.doi.org | Shirong Wang |Xin Xu

2 months ago | elifesciences.org | Shinichi Kawaguchi |Xin Xu |Takashi Soga |Kenta Yamaguchi

eLife Assessment This useful study employs AlphaFold2 to predict interactions among 20 nuage proteins, identifying 5 novel interaction candidates, 3 of which are validated experimentally through co-immunoprecipitation. Expanding the analysis to 430 oogenesis-related proteins and screening ~12,000 Drosophila proteins for interactions with Piwi, the study identifies 164 potential binding partners, demonstrating how computational predictions can streamline experimental validation.

2 months ago | cell.com | Mona Teng |Jiacheng Guo |Xin Xu |Xinpei Ci |Yulin Mo |Yakup Kohen | +22 more

Keywords circular RNA noncoding RNA neuroedocrine prostate cancer small cell lung cancer transcription factors RNA protein interactions lineage plasticity Introduction Circular RNA (circRNA) is a class of noncoding RNA (ncRNA) primarily generated by backsplicing.2,3 The circularization can be promoted through the binding of reverse complementary repetitive sequences in the flanking introns or the dimerization of RNA-binding proteins.2,4 Due to the lack of poly(A) tail, circRNA is...

2 months ago | mdpi.com | Mengying Wang |Xin Xu |Yingtao Qi |Dingqing Zhang

1. IntroductionNowadays, the renewal and conservation of urban historical districts has emerged as a crucial subject in the fields of urban planning and architecture. Historical districts, as significant components of cultural heritage [1], bear regional memories and hold considerable historical and cultural value. Protecting their tangible and intangible value and establishing the local identity of these places are key steps towards achieving sustainable development goals [2].