Xin Xu

1 month ago | elifesciences.org | Shinichi Kawaguchi |Xin Xu |Takashi Soga |Kenta Yamaguchi

eLife Assessment This useful study employs AlphaFold2 to predict interactions among 20 nuage proteins, identifying 5 novel interaction candidates, 3 of which are validated experimentally through co-immunoprecipitation. Expanding the analysis to 430 oogenesis-related proteins and screening ~12,000 Drosophila proteins for interactions with Piwi, the study identifies 164 potential binding partners, demonstrating how computational predictions can streamline experimental validation.

1 month ago | cell.com | Mona Teng |Jiacheng Guo |Xin Xu |Xinpei Ci |Yulin Mo |Yakup Kohen | +22 more

Keywords circular RNA noncoding RNA neuroedocrine prostate cancer small cell lung cancer transcription factors RNA protein interactions lineage plasticity Introduction Circular RNA (circRNA) is a class of noncoding RNA (ncRNA) primarily generated by backsplicing.2,3 The circularization can be promoted through the binding of reverse complementary repetitive sequences in the flanking introns or the dimerization of RNA-binding proteins.2,4 Due to the lack of poly(A) tail, circRNA is...

2 months ago | mdpi.com | Mengying Wang |Xin Xu |Yingtao Qi |Dingqing Zhang

1. IntroductionNowadays, the renewal and conservation of urban historical districts has emerged as a crucial subject in the fields of urban planning and architecture. Historical districts, as significant components of cultural heritage [1], bear regional memories and hold considerable historical and cultural value. Protecting their tangible and intangible value and establishing the local identity of these places are key steps towards achieving sustainable development goals [2].

2 months ago | journals.ametsoc.org | Xuelong Chen |Xin Xu |Qiang Zhang |Yajing Liu

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Feb 21, 2025 | biorxiv.org | Xin Xu |Jonathan Merritt |Steven Gray |Jeffrey L. Neul

AbstractApproximately 60% of individuals with Rett syndrome (RTT) carry a nonsense variant in the MECP2 gene; thus, there is an unmet need to identify novel nonsense suppression compound(s) that can restore full length MeCP2 protein levels and function. Here, we characterized neuronal phenotypes in cultured cortical neurons from newborn knock-in mice harboring the MECP2 R255X variant.