Jung-Ki Yoon

Mar 19, 2025 | nature.com | Jung-Ki Yoon |Yili Zhu |John Lu |Georgios Mikos |Camille Brenac |Nicholas J. Guardino | +6 more

AbstractFibrosis, the replacement of healthy tissue with collagen-rich matrix, can occur following injury in almost every organ1,2. Mouse lungs follow a stereotyped sequence of fibrogenesis-to-resolution after bleomycin injury3, and we reasoned that profiling post-injury histological stages could uncover pro-fibrotic versus anti-fibrotic features with functional value for human fibrosis. Here we quantified spatiotemporally resolved matrix transformations for integration with multi-omic data.

Jul 19, 2023 | nature.com | Jung-Ki Yoon |Joseph Shrager |Rahul Sinha

AbstractMany cancers originate from stem or progenitor cells hijacked by somatic mutations that drive replication, exemplified by adenomatous transformation of pulmonary alveolar epithelial type II (AT2) cells1. Here we demonstrate a different scenario: expression of KRAS(G12D) in differentiated AT1 cells reprograms them slowly and asynchronously back into AT2 stem cells that go on to generate indolent tumours.