Nicholas J. Guardino

1 month ago | nature.com | Jung-Ki Yoon |Yili Zhu |John Lu |Georgios Mikos |Camille Brenac |Nicholas J. Guardino | +6 more

AbstractFibrosis, the replacement of healthy tissue with collagen-rich matrix, can occur following injury in almost every organ1,2. Mouse lungs follow a stereotyped sequence of fibrogenesis-to-resolution after bleomycin injury3, and we reasoned that profiling post-injury histological stages could uncover pro-fibrotic versus anti-fibrotic features with functional value for human fibrosis. Here we quantified spatiotemporally resolved matrix transformations for integration with multi-omic data.