Junzhe Xiao

Oct 12, 2024 | dx.doi.org | Junzhe Xiao |Andrew Myers

Journal of the American Chemical SocietyCite this: J. Am. Chem. Soc. 2024, XXXX, XXXClick to copy citationCitation copied!Learn about these metricsArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days. Citations are the number of other articles citing this article, calculated by Crossref and updated daily.

Oct 12, 2024 | pubs.acs.org | Junzhe Xiao |Andrew Myers |Kelvin J. Y |Richard Porter

Introduction and BackgroundClick to copy section linkSection link copied!The lincosamide antibiotics inhibit bacterial protein synthesis by binding to the 50S subunit of the bacterial ribosome, near the peptidyl transferase center. (1) The last lincosamide antibiotic to receive FDA approval for human use was clindamycin, in 1970, but after more than 50 years of use in hospitals and the community, bacterial resistance to clindamycin is now widespread.