Kaiyi Jiang

Jan 2, 2025 | science.org | Xiaoyu Yang |Jason W. Rocks |Kaiyi Jiang |Jing Liu |Pankaj Mehta |Caleb J. Bashor | +6 more

Protein phosphorylation signaling networks have a central role in how cells sense and respond to their environment. We engineered artificial phosphorylation networks in which reversible enzymatic phosphorylation cycles were assembled from modular protein ...

Nov 21, 2024 | science.org | Chenshu Liu |Feyza Yilmaz |Ayumi Kuratani |Kaiyi Jiang

AbstractDirected protein evolution is central to biomedical applications but faces challenges like experimental complexity, inefficient multi-property optimization, and local maxima traps. While in silico methods using protein language models (PLMs) can provide modeled fitness landscape guidance, they struggle to generalize across diverse protein families and map to protein activity.