Karen Oliver

Aug 20, 2024 | cell.com | Colin Ellis |Karen Oliver |Rebekah Harris |Ruth Ottman

Summary Polygenic risk scores (PRSs) are an important tool for understanding the role of common genetic variants in human disease. Standard best practices recommend that PRSs be analyzed in cohorts that are independent of the genome-wide association study (GWAS) used to derive the scores without sample overlap or relatedness between the two cohorts.

May 13, 2024 | onlinelibrary.wiley.com | Colin Ellis |Danni Tu |Karen Oliver |Heather C Mefford

Objective To assess the possible effects of genetics on seizure outcome by estimating the familial aggregation of three outcome measures: seizure remission, history of ≥4 tonic–clonic seizures, and seizure control for individuals taking antiseizure medication. Methods We analyzed families containing multiple persons with epilepsy in four previously collected retrospective cohorts. Seizure remission was defined as being 5 and 10 years seizure-free at last observation.