Rebekah Harris

Aug 20, 2024 | cell.com | Colin Ellis |Karen Oliver |Rebekah Harris |Ruth Ottman

Summary Polygenic risk scores (PRSs) are an important tool for understanding the role of common genetic variants in human disease. Standard best practices recommend that PRSs be analyzed in cohorts that are independent of the genome-wide association study (GWAS) used to derive the scores without sample overlap or relatedness between the two cohorts.