Karina Farias

San Antonio

Project Coordinator at Edison Research

Music Snob. Feisty Latina. Tattoo Enthusiast. Living Kidney Donor. Texan. Radio Chick turned Research Nerd. #DonateLife 💚

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Articles

NRH, a potent NAD+ booster, improves glucose homeostasis and lipid metabolism in diet-induced obese mice though an active adenosine kinase pathway.

Aug 30, 2024 | biorxiv.org | Yongjie Wang |Karina Farias |Andrew Rappa |Xinliu Zeng

AbstractNAD+ deficiency underlies obesity-induced metabolic disturbances. Here we evaluated the treatment effect of a new and potent NAD+ enhancer, dihydronicotinamide riboside (NRH), in diet-induced obese mice with hyperglycemia and hyperlipidemia. Administering NRH for 7 weeks improved glucose homeostasis by enhancing pancreatic beta-cell functional mass, increasing muscle insulin sensitivity, and reducing hepatic gluconeogenesis.