Karl Deisseroth

Jul 29, 2024 | nature.com | Xiaoyu Chen |Karl Deisseroth

AbstractHuman neural organoids represent promising models for studying neural function; however, organoids grown in vitro lack certain microenvironments and sensory inputs that are thought to be essential for maturation. The transplantation of patient-derived neural organoids into animal hosts helps overcome some of these limitations and offers an approach for neural organoid maturation and circuit integration.

Jun 19, 2024 | nature.com | Anqi Zhang |Karl Deisseroth

AbstractCells execute remarkable functions using biopolymers synthesized from natural building blocks. Engineering cells to leverage the vast array of synthesizable abiotic polymers could provide enhanced or entirely new cellular functions. Here we discuss the applications of in situ-synthesized abiotic polymers in three distinct domains: intracellular polymerization, cell-surface polymerization and extracellular polymerization.

Nov 8, 2023 | nature.com | Karl Deisseroth

AbstractAnimals perform flexible goal-directed behaviours to satisfy their basic physiological needs1,2,3,4,5,6,7,8,9,10,11,12. However, little is known about how unitary behaviours are chosen under conflicting needs. Here we reveal principles by which the brain resolves such conflicts between needs across time. We developed an experimental paradigm in which a hungry and thirsty mouse is given free choices between equidistant food and water.

Sep 13, 2023 | nature.com | Sebastien Tremblay |Sébastien Tremblay |Ilyas Singeç |Clifford J. Woolf |Matthew Hayes |F. Christian Bennett | +4 more

AbstractWith concurrent global epidemics of chronic pain and opioid use disorders, there is a critical need to identify, target and manipulate specific cell populations expressing the mu-opioid receptor (MOR). However, available tools and transgenic models for gaining long-term genetic access to MOR+ neural cell types and circuits involved in modulating pain, analgesia and addiction across species are limited.