Katherine Pak

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Articles

Myositis-specific autoantibodies recognizing Mi2 also target the autoimmune regulator (AIRE) protein at a shared PHD-zinc finger

Jan 19, 2025 | biorxiv.org | Sahana Jayaraman |Katherine Pak |Iago Pinal-Fernandez |Jon Musai

AbstractObjectives: In dermatomyositis patients with anti-Mi2 autoantibodies, autoantibodies can enter muscle cells, leading to the aberrant expression of genes normally repressed by the Mi2/nucleosome remodeling and deacetylation (NuRD) complex. However, the mechanism by which autoantibodies interfere with Mi2/NuRD function remains unclear.

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