Iago Pinal-Fernandez

Jan 19, 2025 | biorxiv.org | Sahana Jayaraman |Katherine Pak |Iago Pinal-Fernandez |Jon Musai

AbstractObjectives: In dermatomyositis patients with anti-Mi2 autoantibodies, autoantibodies can enter muscle cells, leading to the aberrant expression of genes normally repressed by the Mi2/nucleosome remodeling and deacetylation (NuRD) complex. However, the mechanism by which autoantibodies interfere with Mi2/NuRD function remains unclear.

Jun 26, 2024 | nature.com | Catalina Abad |Iago Pinal-Fernandez |Gwladys Bourdenet |Léa Debrut |Sophie Bernard |Andrew L. Mammen

AbstractIdiopathic inflammatory myopathies (IIMs) are severe autoimmune diseases with poorly understood pathogenesis and unmet medical needs. Here, we examine the role of interferon γ (IFNγ) using NOD female mice deficient in the inducible T cell co-stimulator (Icos), which have previously been shown to develop spontaneous IFNγ-driven myositis mimicking human disease. Using muscle proteomic and spatial transcriptomic analyses we reveal profound myofiber metabolic dysregulation in these mice.

Feb 21, 2024 | nature.com | Komudi Singh |Mark Hallett |Kong Chen |Yoshimi Enose-Akahata |Jennifer J. Barb |Patrick Bedard | +22 more

AbstractPost-infectious myalgic encephalomyelitis/chronic fatigue syndrome (PI-ME/CFS) is a disabling disorder, yet the clinical phenotype is poorly defined, the pathophysiology is unknown, and no disease-modifying treatments are available. We used rigorous criteria to recruit PI-ME/CFS participants with matched controls to conduct deep phenotyping.