Kathi Ging

Apr 28, 2024 | biorxiv.org | Adriano Aguzzi |Jiang-An Yin |David J. Vocadlo |Kathi Ging

AbstractMutations in the GBA gene, which encodes the lysosomal enzyme β-glucocerebrosidase (GCase), are the most prevalent genetic susceptibility factor for Parkinson's disease (PD). However, only approximately 20% of carriers develop the disease, suggesting the presence of genetic modifiers influencing the risk of developing PD in the presence of GBA mutations.