Kathleen C. Barnes

May 6, 2024 | nature.com | Yash Pershad |Adrienne M. Stilp |Braxton D. Mitchell |Joshua Lewis |Nathalie Chami |Zhe Wang | +21 more

AbstractClonal hematopoiesis (CH) is characterized by the acquisition of a somatic mutation in a hematopoietic stem cell that results in a clonal expansion. These driver mutations can be single nucleotide variants in cancer driver genes or larger structural rearrangements called mosaic chromosomal alterations (mCAs). The factors that influence the variations in mCA fitness and ultimately result in different clonal expansion rates are not well understood.

Oct 30, 2023 | nature.com | Yasminka A. Jakubek |Adrienne M. Stilp |Justin Wong |Zuhal Özcan |Kathleen C. Barnes |Joshua C. Bis | +22 more

AbstractMegabase-scale mosaic chromosomal alterations (mCAs) in blood are prognostic markers for a host of human diseases. Here, to gain a better understanding of mCA rates in genetically diverse populations, we analyzed whole-genome sequencing data from 67,390 individuals from the National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine program.

May 17, 2023 | tasteforlife.com | Kathleen C. Barnes

Problems with some Cox 2-inhibiting drugs have created concern among the millions of Americans who suffer from osteoarthritis (OA). The good news is that natural alternatives are available. Safe and effective, some of these pain relievers have been shown to slow the progression of osteoarthritis and even reverse damage. Inflammation and PainAll types of arthritis are characterized by chronic inflammation.

Apr 12, 2023 | nature.com | Joshua Weinstock |Bala Bharathi Burugula |Mesbah Uddin |Bence Daniel |Shaneice Mitchell |Cecelia Laurie | +41 more

AbstractMutations in a diverse set of driver genes increase the fitness of haematopoietic stem cells (HSCs), leading to clonal haematopoiesis1. These lesions are precursors for blood cancers2,3,4,5,6, but the basis of their fitness advantage remains largely unknown, partly owing to a paucity of large cohorts in which the clonal expansion rate has been assessed by longitudinal sampling.