Kathrin Brockmann

Jun 18, 2024 | nature.com | Wiebke Möbius |Eckhard Mandelkow |Nicoleta Carmen Cosma |Josef Priller |Andrea Kuhn |Kathrin Brockmann | +16 more

AbstractMinimally invasive biomarkers are urgently needed to detect molecular pathology in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Here, we show that plasma extracellular vesicles (EVs) contain quantifiable amounts of TDP-43 and full-length tau, which allow the quantification of 3-repeat (3R) and 4-repeat (4R) tau isoforms.