Andrea Kuhn

Aug 20, 2024 | nature.com | Nanditha Rajamani |Konstantin Butenko |Barbara Hollunder |Petra Ritter |Michael Fox |Andrea Kuhn | +2 more

Correction to: Nature Communications https://doi.org/10.1038/s41467-024-48731-1, published online 31 May 2024The original version of this Article contained an error in Figure 2, in which the statistical analyses in the insets of panel B were incorrectly reported. Permutation tests were inadvertently reported instead of circular tests and cross-validation values.

Jun 18, 2024 | nature.com | Wiebke Möbius |Eckhard Mandelkow |Nicoleta Carmen Cosma |Josef Priller |Andrea Kuhn |Kathrin Brockmann | +16 more

AbstractMinimally invasive biomarkers are urgently needed to detect molecular pathology in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Here, we show that plasma extracellular vesicles (EVs) contain quantifiable amounts of TDP-43 and full-length tau, which allow the quantification of 3-repeat (3R) and 4-repeat (4R) tau isoforms.

May 30, 2024 | nature.com | Nanditha Rajamani |Konstantin Butenko |Barbara Hollunder |Petra Ritter |Michael Fox |Andrea Kuhn | +2 more

AbstractDeep Brain Stimulation can improve tremor, bradykinesia, rigidity, and axial symptoms in patients with Parkinson’s disease. Potentially, improving each symptom may require stimulation of different white matter tracts. Here, we study a large cohort of patients (N = 237 from five centers) to identify tracts associated with improvements in each of the four symptom domains. Tremor improvements were associated with stimulation of tracts connected to primary motor cortex and cerebellum.

Apr 11, 2024 | nature.com | Srdjan Sumarac |Jürgen Germann |Milos R. Popovic |Mojgan Hodaie |Alfonso Fasano |Andres M. Lozano | +2 more

AbstractDeep brain stimulation (DBS) of the subthalamic nucleus (STN) produces an electrophysiological signature called evoked resonant neural activity (ERNA); a high-frequency oscillation that has been linked to treatment efficacy. However, the single-neuron and synaptic bases of ERNA are unsubstantiated. This study proposes that ERNA is a subcortical neuronal circuit signature of DBS-mediated engagement of the basal ganglia indirect pathway network.

Jun 16, 2023 | nature.com | Andrea Kuhn

AbstractIn patients with Parkinson’s disease (PD), suppression of beta and increase in gamma oscillations in the subthalamic nucleus (STN) have been associated with both levodopa treatment and motor functions. Recent results suggest that modulation of the temporal dynamics of theses oscillations (bursting activity) might contain more information about pathological states and behaviour than their average power.