Kathryn Harper

Jun 2, 2024 | eneuro.org | Kathryn Joyce |Julia Lord |Kathryn Harper |Todd Cohen

AbstractSleep disruption and impaired synaptic processes are common features in neurodegenerative diseases, including Alzheimer's disease (AD). Hyperphosphorylated Tau is known to accumulate at neuronal synapses in AD, contributing to synapse dysfunction. However, it remains unclear how sleep disruption and synapse pathology interact to contribute to cognitive decline. Here, we examined sex-specific onset and consequences of sleep loss in AD/tauopathy model PS19 mice.

Jun 1, 2024 | eneuro.org | Kathryn Joyce |Julia Lord |Kathryn Harper |Todd Cohen

MiceAnimal procedures were all approved by the animal care and use committee of the University of North Carolina Chapel Hill (UNC) and performed according to guidelines set by the US National Institutes of Health. P301S (PS19) male mice were obtained from Dr. Todd Cohen (UNC) and bred with C57BL/6J females purchased from the Jackson Laboratory. C57BL/6J females were allowed to acclimate to the housing for at least 2 weeks before breeding.