Todd Cohen

Jun 2, 2024 | eneuro.org | Kathryn Joyce |Julia Lord |Kathryn Harper |Todd Cohen

AbstractSleep disruption and impaired synaptic processes are common features in neurodegenerative diseases, including Alzheimer's disease (AD). Hyperphosphorylated Tau is known to accumulate at neuronal synapses in AD, contributing to synapse dysfunction. However, it remains unclear how sleep disruption and synapse pathology interact to contribute to cognitive decline. Here, we examined sex-specific onset and consequences of sleep loss in AD/tauopathy model PS19 mice.

Jun 1, 2024 | eneuro.org | Kathryn Joyce |Julia Lord |Kathryn Harper |Todd Cohen

MiceAnimal procedures were all approved by the animal care and use committee of the University of North Carolina Chapel Hill (UNC) and performed according to guidelines set by the US National Institutes of Health. P301S (PS19) male mice were obtained from Dr. Todd Cohen (UNC) and bred with C57BL/6J females purchased from the Jackson Laboratory. C57BL/6J females were allowed to acclimate to the housing for at least 2 weeks before breeding.

Dec 8, 2023 | onlinelibrary.wiley.com | Jui-Heng Tseng |Todd Cohen

• , , & ( ). Tau dephosphorylation at tau-1 site correlates with its association to cell membrane . Neurochemical Research, ( ), – . • , , & ( ). Processes induced by tau expression in Sf9 cells have an axon-like microtubule organization . The Journal of Cell Biology, ( ), – . • , & ( ). Tau: It's not what you think . Trends in Cell Biology, ( ), – . • , , , , & ( ). Tau is enriched on dynamic microtubules in the distal region of growing axons . The Journal of Neuroscience, ( ), – . • , , , , , , & ( ).

Jul 11, 2023 | mdpi.com | Kristina M. Kruglyak |Allison L. O’Kell |Todd Cohen |Maggie Marshall

4. DiscussionThe identification of recurrent CNVs in the WBC gDNA of older dogs, which persist with little to no change in amplitude over time and are absent from cfDNA (and from tumor tissue, in dogs with concurrent cancer), provides early evidence for the existence of age-related somatic alterations in dogs that resemble the phenomenon of CHIP previously described in humans.