Kathryn R. Monopoli

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Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin - Nature Communications

Nov 4, 2023 | nature.com | Qi Tang |Hassan Fakih |Vignesh Hariharan |Ashley Summers |Ken Okamura |Kathryn R. Monopoli | +14 more

AbstractInhibition of Janus kinase (JAK) family enzymes is a popular strategy for treating inflammatory and autoimmune skin diseases. In the clinic, small molecule JAK inhibitors show distinct efficacy and safety profiles, likely reflecting variable selectivity for JAK subtypes. Absolute JAK subtype selectivity has not yet been achieved.

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