Qi Tang

Apr 3, 2024 | nature.com | Qi Tang |Anastasia Khvorova

AbstractMore than 25 years after its discovery, the post-transcriptional gene regulation mechanism termed RNAi is now transforming pharmaceutical development, proved by the recent FDA approval of multiple small interfering RNA (siRNA) drugs that target the liver. Synthetic siRNAs that trigger RNAi have the potential to specifically silence virtually any therapeutic target with unprecedented potency and durability.

Nov 16, 2023 | pubs.acs.org | jie wang |Nathania A. Takyi |Yun-Chung Hsiao |Qi Tang

Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Am. Chem. Soc. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).

Nov 4, 2023 | nature.com | Qi Tang |Hassan Fakih |Vignesh Hariharan |Ashley Summers |Ken Okamura |Kathryn R. Monopoli | +14 more

AbstractInhibition of Janus kinase (JAK) family enzymes is a popular strategy for treating inflammatory and autoimmune skin diseases. In the clinic, small molecule JAK inhibitors show distinct efficacy and safety profiles, likely reflecting variable selectivity for JAK subtypes. Absolute JAK subtype selectivity has not yet been achieved.

Jun 12, 2023 | onlinelibrary.wiley.com | Qi Tang |Xing Chen

Cellular proteins are dynamically regulated in response to environmental stimuli. Conventional proteomics compares the entire proteome in different cellular states to identify differentially expressed proteins, which suffers from limited sensitivity for analyzing acute and subtle changes.

May 5, 2023 | onlinelibrary.wiley.com | Peng Tan |Chenchen Wu |Optoelectronics Engineering |Qi Tang

Research Article Abstract Drug-resistant bacteria and biofilm-associated infections are prominent problems in the field of antibacterial medicine, seriously affecting human and animal health. Despite the great potential of nanomaterials in the antibacterial field, overcoming the paradox of size and charge, efficient penetration, and retention within biofilms remain a formidable challenge.