Katie L. Burnham

Jul 24, 2024 | cell.com | Thomas Vanderstichele |Katie L. Burnham |Niek de Klein |Manuel Tardaguila

SummaryGene misexpression is the aberrant transcription of a gene in a context where it is usually inactive. Despite its known pathological consequences in specific rare diseases, we have a limited understanding of its wider prevalence and mechanisms in humans. To address this, we analyzed gene misexpression in 4,568 whole-blood bulk RNA sequencing samples from INTERVAL study blood donors.

Jun 18, 2024 | inkl.com | Katie L. Burnham

PA ArchiveSepsis patients could get the right treatment faster based on their genes, new research suggests. People with the life-threatening condition could be treated based on their immune system’s response to infection, not their symptoms, researchers say. The new study uncovers how different people respond to to the condition based on their genetic makeup.

Jun 5, 2024 | science.org | Yuxin Mi |Jian Liu |Marvin Reich |Katie L. Burnham |Helen F Galley |Jane Taylor | +8 more

Research ArticleSEPSISYuxin Mi https://orcid.org/0000-0002-8194-2977, Katie L. Burnham https://orcid.org/0000-0001-8680-2933, [...] , Philip D. Charles https://orcid.org/0000-0001-5278-5354, Raphael Heilig https://orcid.org/0000-0002-4860-3746, [...] , Iolanda Vendrell https://orcid.org/0000-0001-7187-4061, Justin Whalley https://orcid.org/0000-0002-0403-3091, Hew D. Torrance https://orcid.org/0000-0002-3854-1748, David B. Antcliffe https://orcid.org/0000-0002-1846-9160, Shaun M.

Nov 19, 2023 | biorxiv.org | Katie L. Burnham |Niek de Klein |Manuel Tardaguila |Thomas Vanderstichele

AbstractGene misexpression is the aberrant transcription of a gene in a context where it is usually inactive. Despite its known pathological consequences in specific rare diseases, we have a limited understanding of its wider prevalence and mechanisms in humans. To address this, we analyzed gene misexpression in 4,568 whole blood bulk RNA sequencing samples from INTERVAL study blood donors.