Kay H Hofmann

Nov 3, 2024 | nature.com | Carlos Moreno-Yruela |Sabrina Schulze |Gottfried J. Palm |Nancy Wang |Dianna Hocking |Leila Jebeli | +5 more

AbstractClassical Zn2+-dependent deac(et)ylases play fundamental regulatory roles in life and are well characterized in eukaryotes regarding their structures, substrates and physiological roles. In bacteria, however, classical deacylases are less well understood. We construct a Generalized Profile (GP) and identify thousands of uncharacterized classical deacylases in bacteria, which are grouped into five clusters.

Nov 3, 2024 | nature.com | Carlos Moreno-Yruela |Sabrina Schulze |Gottfried J. Palm |Nancy Wang |Dianna Hocking |Leila Jebeli | +5 more

AbstractClassical Zn2+-dependent deac(et)ylases play fundamental regulatory roles in life and are well characterized in eukaryotes regarding their structures, substrates and physiological roles. In bacteria, however, classical deacylases are less well understood. We construct a Generalized Profile (GP) and identify thousands of uncharacterized classical deacylases in bacteria, which are grouped into five clusters.

Aug 21, 2024 | fis.tu-dresden.de | Kay H Hofmann |Marc Isele |Artur Erbe |Helmholtz-Zentrum Dresden-Rossendorf

Abstract External IDs PubMed 39020999

Jul 25, 2024 | nature.com | Thomas Hermanns |Kay H Hofmann

In a recent study published in Nature, Poirson et al.1 report an unbiased screen for proteins that can either bring about—or prevent—the destruction of proteinaceous model substrates in a proximity-dependent manner. Knowledge of such protein degraders and stabilizers will be instrumental in the development of new drug classes that specifically regulate the abundance of their target proteins.

Jun 3, 2024 | link.aps.org | Kay H Hofmann |Marc Isele |Artur Erbe |Helmholtz-Zentrum Dresden-Rossendorf

Brownian dynamics simulations are utilized to study segregation phenomena far from thermodynamic equilibrium. In the present study, we expand upon the analysis of binary colloid mixtures and introduce a third particle species to further our understanding of colloidal systems. Gravitationally driven, spherical colloids immersed in an implicit solvent are confined in two-dimensional linear microchannels.