Kayshani R Kanagarajah

May 17, 2024 | biorxiv.org | Cheng Wang |Kayshani R Kanagarajah |Amy Wong |Felix Ratjen

AbstractBackground: While cystic fibrosis is caused by loss-of-function variants in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), other modifier genes have been shown to associate with disease severity. Co-expression of modifiers with CFTR in normal tissue indicates a cooperative relationship and suggests the potential for compensation in the presence of CFTR dysfunction.

Oct 28, 2023 | biorxiv.org | Spencer Farrell |Kayshani R Kanagarajah |Michael Wu |Henry Tat Quach

AbstractWhile animal models have provided key insights into conserved mechanisms of how the lung forms during development, human-specific developmental mechanisms are not always captured. To fully appreciate how developmental defects and disease states alter the function of the lungs, studies in human lung models are important.