Kelly Chibale

Sep 23, 2024 | pubs.acs.org | Kelly Chibale

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May 30, 2024 | pubs.acs.org | Schmidt Futures |Jason Hlozek |Kelly Chibale |John Woodland

Special IssuePublished as part of ACS Medicinal Chemistry Letters virtual special issue “Exploring the Use of AI/ML Technologies in Medicinal Chemistry and Drug Discovery”. Developing novel medicines is a lengthy and challenging process. Candidate molecules need to advance through the various stages of the drug discovery pipeline, from hit discovery and medicinal chemistry optimization to clinical trials and ultimately (if successful) regulatory approval.

Mar 22, 2024 | allafrica.com | Kelly Chibale

One hundred and forty-two years after its discovery, Tuberculosis (TB) remains a global public health problem. Despite being preventable and curable, 1.3 million people died from TB in 2022, 424,000 of them in Africa and 54,200 of them in South Africa alone. Statistically, that means one life was lost to TB every 10 minutes in South Africa during that period.

Sep 15, 2023 | nature.com | Gemma Turon |Jason Hlozek |John Woodland |Kumar Ankur |Kelly Chibale

AbstractStreamlined data-driven drug discovery remains challenging, especially in resource-limited settings. We present ZairaChem, an artificial intelligence (AI)- and machine learning (ML)-based tool for quantitative structure-activity/property relationship (QSAR/QSPR) modelling. ZairaChem is fully automated, requires low computational resources and works across a broad spectrum of datasets.

Jul 25, 2023 | spotlightnsp.co.za | Kelly Chibale |Chris Bateman |Elri Voigt |Biénne Huisman

South Africa’s National Strategic Plan for HIV, TB and STIs (2023 – 2028) was launched at Tlhabane Stadium in Rustenburg, North West as the world commemorated World TB Day on 24 March. PHOTO: Denvor de Wee/Spotlight Comment & Analysis25th July 2023 | Marcus Low Making the case for governments and donors to pump money into the HIV response has become more difficult over the last decade.