Ken Prehoda

Oct 29, 2024 | biorxiv.org | Bryce LaFoya |Ken Prehoda

AbstractAfter the first furrowing step of animal cell division, the nascent sibling cells remain connected by a thin intercellular bridge (ICB). In isolated cells nascent siblings migrate away from each other to generate tension and constrict the ICB, but less is known about how cells complete cytokinesis when constrained within tissues.

Oct 1, 2024 | biorxiv.org | Bryce LaFoya |Sarah Welch |Ken Prehoda

AbstractThe Par complex regulates cell polarity in diverse animal cells, but how its localization is restricted to a specific membrane domain remains unclear. We investigate how the tumor suppressor Lethal giant larvae (Lgl) regulates Par complex polarity in Drosophila neural stem cells (NSCs). Unlike in epithelial cells, where Lgl and the Par complex show mutual exclusion, in NSCs the Par complex is apically polarized while Lgl is cytoplasmic during mitosis.