Kendell Clement

3 weeks ago | nature.com | Zheqi Li |Xintao Qiu |Marco Seehawer |Maeve McFadden |Eva Papachristou |Natalie Kingston | +17 more

AbstractBasal breast cancer is a subtype with a poor prognosis in need of more effective therapeutic approaches. Here we describe a unique role for the KDM4C histone lysine demethylase in KDM4C-amplified basal breast cancers, where KDM4C inhibition reshapes chromatin and transcriptomic landscapes without substantial alterations of its canonical substrates, trimethylated histone H3 lysine 9 (H3K9me3) and lysine 36 (H3K36me3).

1 month ago | cell.com | Diana Aguilar-Gómez |Jacob Bejder |Jonathan Graae |Yelin Ko |Andrew Vaughn |Kendell Clement | +5 more

Keywordsevolutionary adaptationnatural selectioncardiovascular physiologybreath-hold divingResearch topic(s)CP: GenomicsIntroductionExtraordinary human populations have inhabited nearly every environment on the planet, adopting unique lifestyles and strategies to survive. The extreme conditions faced by these populations have imposed natural selection, introducing heritable adaptive variation.