Kenneth B. Hoehn

Dec 27, 2023 | cell.com | Kenneth B. Hoehn |Steven Kleinstein

Highlights Phylogenetic trees can be built from B cell receptor (BCR) sequences and used to study somatic hypermutation and selection. The unique biology of B cells has led to the development of B cell-specific phylogenetic methods. Single-cell sequencing can improve tree building with paired heavy and light chain sequences and (potentially) with paired transcriptomic information.