Steven Kleinstein

Jan 10, 2025 | nature.com | Cole Maguire |Nadine Rouphael |William Messer |Matthew Altman |Patrice Becker |Steven E. Bosinger | +9 more

AbstractCoronavirus disease 2019 (COVID-19) poses significant risks for solid organ transplant recipients, who have atypical but poorly characterized immune responses to infection. We aim to understand the host immunologic and microbial features of COVID-19 in transplant recipients by leveraging a prospective multicenter cohort of 86 transplant recipients age- and sex-matched with 172 non-transplant controls.

Jul 3, 2024 | nature.com | Rachel Sparks |William Lau |Rohit Farmer |Yuri Kotliarov |Katherine R. Calvo |Susan Moir | +6 more

AbstractImmunological health has been challenging to characterize but could be defined as the absence of immune pathology. While shared features of some immune diseases and the concept of immunologic resilience based on age-independent adaptation to antigenic stimulation have been developed, general metrics of immune health and its utility for assessing clinically healthy individuals remain ill defined.

Apr 11, 2024 | academic.oup.com | Ct Usa |Steven Kleinstein

Predictive biological signatures provide utility as biomarkers for disease diagnosis and prognosis, as well as prediction of responses to vaccination or therapy. These signatures are identified from high-throughput profiling assays through a combination of dimensionality reduction and machine learning techniques.

Dec 27, 2023 | cell.com | Kenneth B. Hoehn |Steven Kleinstein

Highlights Phylogenetic trees can be built from B cell receptor (BCR) sequences and used to study somatic hypermutation and selection. The unique biology of B cells has led to the development of B cell-specific phylogenetic methods. Single-cell sequencing can improve tree building with paired heavy and light chain sequences and (potentially) with paired transcriptomic information.