Kenneth Baker

Nov 27, 2024 | cell.com | Lucy Macdonald |Aziza Elmesmari |Domenico Somma |Jack Frew |Clara Di Mario |Roopa Madhu | +30 more

Keywordsimmune tolerancearthritisdisease remissiondendritic cellssynovial tissuespatial transcriptomicsT cellsIntroductionRheumatoid arthritis (RA) is an inflammatory joint disease with systemic comorbidities, driven by the breach of immune tolerance.1 Advances in targeted therapies2 have transformed the management of RA.

Oct 1, 2023 | thetimes.co.uk | Kenneth Baker

Rishi Sunak has decided the best way to win the election is to be the “change” candidate — his first change is the approach to net zero. He also wants to change education. That’s good news, for in the 1980s as the education secretary I was only able to bring in major reforms with the support of Margaret Thatcher. SponsoredChange today must recognise the real and urgent needs of British industry for their future employees to have technical and practical skills, particularly digital and data.

Aug 30, 2023 | neurologylive.com | Kenneth Baker

WATCH TIME: 3 minutes"The remarkable part was how, even with modest expectations due to the limited sample size, we were genuinely excited by the outcomes of the initial patient and those that followed. Witnessing our ability to achieve and sometimes exceed the targeted benefits was undoubtedly a high point."Despite improvements in outcomes in the early hours after stroke, technological leaps for the post-acute phase have been slower.

Aug 22, 2023 | neurologylive.com | Kenneth Baker

WATCH TIME: 3 minutes"We use stimulation at around 30 hz because we’re trying to actually augment a pathway, trying to enhance activity across a specific pathway in order to enhance the cortical excitability that we think will underlie the functional reorganization."Over the last decade, deep brain stimulation (DBS) has become the most commonly used surgical approach for patients with essential tremor and Parkinson disease, sending electrical pulses to the brain to help control motor symptoms.

Aug 14, 2023 | nature.com | Kenneth Baker |Olivia Hogue |Darlene Floden |Paul Ford |Bo Hu

AbstractUpper-extremity impairment after stroke remains a major therapeutic challenge and a target of neuromodulation treatment efforts. In this open-label, non-randomized phase I trial, we applied deep brain stimulation to the cerebellar dentate nucleus combined with renewed physical rehabilitation to promote functional reorganization of ipsilesional cortex in 12 individuals with persistent (1–3 years), moderate-to-severe upper-extremity impairment.