Kenneth Westerman

1 month ago | nature.com | Magdalena Sevilla-Gonzalez |Elizabeth Litkowski |Hyunkyung Kim |Ching-Ti Liu |Chenglong Yu |John McNeil | +12 more

AbstractElevated fasting insulin levels (FI), indicative of altered insulin secretion and sensitivity, may precede type 2 diabetes (T2D) and cardiovascular disease onset. In this study, we group FI-associated genetic variants based on their genetic and phenotypic similarities and identify seven clusters with distinct mechanisms contributing to elevated FI levels.

Sep 10, 2024 | medrxiv.org | Kenneth Westerman |Chirag Patel |Daniel I. Chasman |James B Meigs

The authors have declared no competing interest. KEW was supported by K01DK133637. JBM was supported by UM1DK078616 and R01HL151855. AKM was supported by R01HL145025. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

Apr 4, 2024 | cell.com | Kenneth Westerman |Tamar Sofer

SummaryDespite the importance of gene-environment interactions (GxEs) in improving and operationalizing genetic discovery, interpretation of any GxEs that are discovered can be surprisingly difficult. There are many potential biological and statistical explanations for a statistically significant finding and, likewise, it is not always clear what can be claimed based on a null result.