Kenta Yamaguchi

2 months ago | elifesciences.org | Shinichi Kawaguchi |Xin Xu |Takashi Soga |Kenta Yamaguchi

eLife Assessment This useful study employs AlphaFold2 to predict interactions among 20 nuage proteins, identifying 5 novel interaction candidates, 3 of which are validated experimentally through co-immunoprecipitation. Expanding the analysis to 430 oogenesis-related proteins and screening ~12,000 Drosophila proteins for interactions with Piwi, the study identifies 164 potential binding partners, demonstrating how computational predictions can streamline experimental validation.