Kesatebrhan Haile Asressu

Sep 5, 2024 | dx.doi.org | Anirban Ghoshal |Kesatebrhan Haile Asressu |Mohammad Hossain |Peter Brown

IntroductionClick to copy section linkSection link copied!Alphaviruses, a group of widespread and enveloped RNA viruses, pose a significant threat to public health due to their transmission by broadly distributed mosquito vectors, such as Aedes aegypti and Aedes albopictus mosquitoes. (1) These viruses have been placed into two distinct categories based on their geographical origin: Old World alphaviruses and New World alphaviruses, each associated with unique clinical manifestations.

Jun 13, 2024 | biorxiv.org | Anirban Ghoshal |Kesatebrhan Haile Asressu |Mohammad Hossain |Peter Brown

AbstractDespite their widespread impact on human health there are no approved drugs for combating alphavirus infections. The heterocyclic β-aminomethyl vinyl sulfone RA-0002034 (1a) is a potent irreversible covalent inhibitor of the alphavirus nsP2 cysteine protease with broad spectrum antiviral activity.