
Kevin Cutler
Articles
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1 month ago |
biorxiv.org | Prateek Sehgal |Andrea Shaw |Kevin Cutler |Bridget Letson
AbstractLive biotherapeutic products (LBPs) are emerging as powerful tools to modulate the microbiome using well-defined microbial communities. Yet, designing, manufacturing, and delivering LBPs remains challenging, in part due to a lack of technologies capable of analyzing LBPs as complete, spatially organized consortia. Conventional sequencing-based methods lack sensitivity and specificity and do not provide critical spatial information.
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Apr 17, 2024 |
nature.com | Young-Jun Park |Kevin Cutler |Kyle L. Asfahl |Larry Gallagher |Frank DiMaio |Dapeng Zhang | +2 more
AbstractStreptomyces are a genus of ubiquitous soil bacteria from which the majority of clinically utilized antibiotics derive1. The production of these antibacterial molecules reflects the relentless competition Streptomyces engage in with other bacteria, including other Streptomyces species1,2. Here we show that in addition to small-molecule antibiotics, Streptomyces produce and secrete antibacterial protein complexes that feature a large, degenerate repeat-containing polymorphic toxin protein.
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