Frank DiMaio

Dec 2, 2024 | nature.com | Yagoub Adam |Robert T. Batey |Eugene F. Baulin |Janusz M Bujnicki |Kristy A. Carpenter |Wah Chiu | +44 more

AbstractRNA-Puzzles is a collective endeavor dedicated to the advancement and improvement of RNA three-dimensional structure prediction. With agreement from structural biologists, RNA structures are predicted by modeling groups before publication of the experimental structures. We report a large-scale set of predictions by 18 groups for 23 RNA-Puzzles: 4 RNA elements, 2 Aptamers, 4 Viral elements, 5 Ribozymes and 8 Riboswitches.

Apr 17, 2024 | nature.com | Young-Jun Park |Kevin Cutler |Kyle L. Asfahl |Larry Gallagher |Frank DiMaio |Dapeng Zhang | +2 more

AbstractStreptomyces are a genus of ubiquitous soil bacteria from which the majority of clinically utilized antibiotics derive1. The production of these antibacterial molecules reflects the relentless competition Streptomyces engage in with other bacteria, including other Streptomyces species1,2. Here we show that in addition to small-molecule antibiotics, Streptomyces produce and secrete antibacterial protein complexes that feature a large, degenerate repeat-containing polymorphic toxin protein.