Kevin J. Zemaitis

Feb 13, 2024 | biorxiv.org | Kevin J. Zemaitis |James M. Fulcher |Rashmi Kumar |David Degnan

AbstractBackground: The Human Proteome Project has credibly detected nearly 93% of the roughly 20,000 proteins which are predicted by the human genome. However, the proteome is enigmatic, where alterations in amino acid sequences from polymorphisms and alternative splicing, errors in translation, and post-translational modifications result in a proteome depth estimated at several million unique proteoforms.