Kimberley Billingsley

2 months ago | digitalcommons.library.tmc.edu | Mikhail Kolmogorov |Kimberley Billingsley |Mira Mastoras |Melissa Meredith

KeywordsHumans, Sequence Analysis, DNA, Haplotypes, Genome, Human, Nanopore Sequencing, Methylation, Pilot Projects, High-Throughput Nucleotide SequencingAbstractLong-read sequencing technologies substantially overcome the limitations of short-reads but have not been considered as a feasible replacement for population-scale projects, being a combination of too expensive, not scalable enough or too error-prone.

May 3, 2024 | medrxiv.org | Guillaume Cogan |Kensuke Daida |Kimberley Billingsley |Christelle Tesson

The authors have declared no competing interest. This work was supported in part by the Intramural Research Programs of the National Institute on Aging (NIA). This work was also supported by the Fondation pour la Recherche Medicale (FRM, MND202004011718), the Fondation de France, la Federation pour la Recherche sur le Cerveau (FRC), France-Parkinson Association, and the French program "Investissements d'avenir" (ANR-10-IAIHU-06).

Sep 14, 2023 | nature.com | Mikhail Kolmogorov |Kimberley Billingsley |Mira Mastoras |Melissa Meredith |Ramita Dewan |Kensuke Daida | +13 more

AbstractLong-read sequencing technologies substantially overcome the limitations of short-reads but have not been considered as a feasible replacement for population-scale projects, being a combination of too expensive, not scalable enough or too error-prone. Here we develop an efficient and scalable wet lab and computational protocol, Napu, for Oxford Nanopore Technologies long-read sequencing that seeks to address those limitations.