Kimberley Burrows

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A framework for conducting GWAS using repeated measures data with an application to childhood BMI - Nature Communications

Nov 20, 2024 | nature.com | Kimberley Burrows |Anni Heiskala |Mathilde Boissel |Yee-Ming Chan |Philippe Froguel |Hakon Hakonarson | +8 more

AbstractGenetic effects on changes in human traits over time are understudied and may have important pathophysiological impact. We propose a framework that enables data quality control, implements mixed models to evaluate trajectories of change in traits, and estimates phenotypes to identify age-varying genetic effects in GWAS.

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