Philippe Froguel

Jan 13, 2025 | thelancet.com | Philippe Froguel

Get full text accessLog in, subscribe or purchase for full access. References1. Ong, KL ∙ Stafford, LK ∙ McLaughlin, SA ∙ et al. Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021Lancet. 2023; 402:203-2342. Magliano, D ∙ Boyko, EJIDF diabetes atlas3. ElSayed, NA ∙ Aleppo, G ∙ Aroda, VR ∙ et al.

Nov 20, 2024 | nature.com | Kimberley Burrows |Anni Heiskala |Mathilde Boissel |Yee-Ming Chan |Philippe Froguel |Hakon Hakonarson | +8 more

AbstractGenetic effects on changes in human traits over time are understudied and may have important pathophysiological impact. We propose a framework that enables data quality control, implements mixed models to evaluate trajectories of change in traits, and estimates phenotypes to identify age-varying genetic effects in GWAS.

Sep 7, 2023 | nature.com | Alessia Faggian |Alessia David |Reedik Mägi |Emma Ahlqvist |Gudmar Thorleifsson |Robert Scott | +37 more

AbstractConventional measurements of fasting and postprandial blood glucose levels investigated in genome-wide association studies (GWAS) cannot capture the effects of DNA variability on ‘around the clock’ glucoregulatory processes. Here we show that GWAS meta-analysis of glucose measurements under nonstandardized conditions (random glucose (RG)) in 476,326 individuals of diverse ancestries and without diabetes enables locus discovery and innovative pathophysiological observations.

Aug 2, 2023 | nature.com | Yanick Hagemeijer |Albert Smith |Claudia Schurmann |Jennifer Brody |Gardar Sveinbjornsson |Cécile Lecoeur | +82 more

Method detailsPopulationsThe full RHR meta-analysis included 100 studies with data on RHR in up to 835,465 individuals. RHR was obtained from ECG in 54 studies, from pulse rate in 31 studies (of which seven were self-measured by the participants), from blood pressure monitor in nine studies, from electronic medical records in three studies, from manual measurement in one study and through a combination of multiple of the before mentioned methods in two studies.

Feb 28, 2023 | time.news | Philippe Froguel

Fighting obesity in young people is the best way to greatly reduce the number of obese adults and associated diseases (diabetes, liver, cardiovascular or pulmonary diseases, cancers, joint disorders, etc.). Childhood obesity has soared in Europe with Covid-related movement restrictions.