Kimberly A. Leonhard

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Cytogenetic resource enables mechanistic resolution of changing trends in human pluripotent stem cell aberrations linked to feeder-free culture

Sep 21, 2023 | biorxiv.org | Dylan Stavish |Christopher Price |Gabriele Gelezauskaite |Kimberly A. Leonhard

AbstractSince the first derivation of human pluripotent stem cells (hPSCs), the number of culture conditions has steadily increased, making hPSC culture more facile. Nonetheless, there remains the persistent issue of culture-acquired genetic changes, hampering the reproducibility of hPSC research and jeopardising their clinical use.

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