Kin Fan

Jan 21, 2025 | nature.com | Ankur Garg |Kin Fan |Yang Xiao |Yael David

AbstractGlycation, a non-enzymatic post-translational modification occurring on proteins, can be actively reversed via site-specific phosphorylation of the fructose-lysine moiety by FN3K kinase, to impact the cellular function of the target protein. A regulatory axis between FN3K and glycated protein targets has been associated with conditions like diabetes and cancer. However, the molecular basis of this relationship has not been explored so far.

Aug 5, 2024 | biorxiv.org | Ankur Garg |Yang Xiao |Elad Elkayam |Kin Fan

AbstractGlycation, a non-enzymatic post-translational modification occurring on proteins, can be actively reversed via site-specific phosphorylation of the fructose-lysine moiety by FN3K kinase, to impact the cellular function of target protein. A regulatory axis between FN3K and glycated protein targets has been associated with conditions like diabetes and cancer. However the molecular basis of this relationship has not been explored so far.