Yael David

2 months ago | cell.com | Emily R Feierman |Sean Louzon |Nicholas Prescott |Tracy Biaco |Qingzeng Gao |Qi Qiu | +10 more

2 months ago | cell.com | Emily R Feierman |Sean Louzon |Nicholas Prescott |Tracy Biaco |Qingzeng Gao |Qi Qiu | +10 more

In the originally published version of this article, the authors inadvertently included an extra “4” in the GSE number listed in the Deposited data section of the key resources table for the paper’s raw and analyzed sequencing data. The correct number, “GSE246688,” is now included in the table. The authors apologize for the error and any confusion that may have resulted.

Jan 21, 2025 | nature.com | Ankur Garg |Kin Fan |Yang Xiao |Yael David

AbstractGlycation, a non-enzymatic post-translational modification occurring on proteins, can be actively reversed via site-specific phosphorylation of the fructose-lysine moiety by FN3K kinase, to impact the cellular function of the target protein. A regulatory axis between FN3K and glycated protein targets has been associated with conditions like diabetes and cancer. However, the molecular basis of this relationship has not been explored so far.

Jan 8, 2025 | nature.com | Qingfei Zheng |Shuai Zhao |Stephanie Stransky |Giuseppina Di Salvo |Jinghua Wu |Lauren E Vostal | +8 more

AbstractHistone H3 monoaminylations at Gln5 represent an important family of epigenetic marks in brain that have critical roles in permissive gene expression1,2,3. We previously demonstrated that serotonylation4,5,6,7,8,9,10 and dopaminylation9,11,12,13 of Gln5 of histone H3 (H3Q5ser and H3Q5dop, respectively) are catalysed by transglutaminase 2 (TG2), and alter both local and global chromatin states.

Jan 22, 2024 | nature.com | Albert S Agustinus |Yael David

Here we investigate the role of epigenetics in the formation, transcription regulation, maintenance and termination of several non-canonical chromatin structures. Using two examples, we demonstrate how studying non-canonical structures may reveal underlying mechanisms with implications for disease and propose intriguing epigenetic avenues for further exploration. Human DNA, approximately 3 billion base pairs in length, is organized into chromosomes.