Yael David

Jan 21, 2025 | nature.com | Ankur Garg |Kin Fan |Yang Xiao |Yael David

AbstractGlycation, a non-enzymatic post-translational modification occurring on proteins, can be actively reversed via site-specific phosphorylation of the fructose-lysine moiety by FN3K kinase, to impact the cellular function of the target protein. A regulatory axis between FN3K and glycated protein targets has been associated with conditions like diabetes and cancer. However, the molecular basis of this relationship has not been explored so far.

Jan 8, 2025 | nature.com | Qingfei Zheng |Shuai Zhao |Stephanie Stransky |Giuseppina Di Salvo |Jinghua Wu |Lauren E Vostal | +8 more

AbstractHistone H3 monoaminylations at Gln5 represent an important family of epigenetic marks in brain that have critical roles in permissive gene expression1,2,3. We previously demonstrated that serotonylation4,5,6,7,8,9,10 and dopaminylation9,11,12,13 of Gln5 of histone H3 (H3Q5ser and H3Q5dop, respectively) are catalysed by transglutaminase 2 (TG2), and alter both local and global chromatin states.

Jan 22, 2024 | nature.com | Albert S Agustinus |Yael David

Here we investigate the role of epigenetics in the formation, transcription regulation, maintenance and termination of several non-canonical chromatin structures. Using two examples, we demonstrate how studying non-canonical structures may reveal underlying mechanisms with implications for disease and propose intriguing epigenetic avenues for further exploration. Human DNA, approximately 3 billion base pairs in length, is organized into chromosomes.

Jun 7, 2023 | nature.com | Albert S Agustinus |Stephanie Stransky |Lorenzo Scipioni |Jens Luebeck |Robert Myers |Britta Weigelt | +13 more

AbstractChromosomal instability (CIN) and epigenetic alterations are characteristics of advanced and metastatic cancers1,2,3,4, but whether they are mechanistically linked is unknown. Here we show that missegregation of mitotic chromosomes, their sequestration in micronuclei5,6 and subsequent rupture of the micronuclear envelope7 profoundly disrupt normal histone post-translational modifications (PTMs), a phenomenon conserved across humans and mice, as well as in cancer and non-transformed cells.