Kirill Batmanov

Feb 8, 2023 | science.org | Scott Parker |Dennis Odera |Yang Xiao |Kirill Batmanov

LATEST NEWS AbstractCurrent therapeutic strategies for treating nonalcoholic steatohepatitis (NASH) have failed to alleviate liver fibrosis, which is a devastating feature leading to hepatic dysfunction. Here, we integrated single-nucleus transcriptomics and epigenomics to characterize all major liver cell types during NASH development in mice and humans. The bifurcation of hepatocyte trajectory with NASH progression was conserved between mice and humans.