Dennis Odera

May 23, 2024 | cell.com | Irene N. Nkumama |Rodney Ogwang |Dennis Odera |Fauzia Musasia

Highlights•Used a human malaria infection study to investigate functional correlates of immunity•IgG Fc-dependent mechanisms are correlated with acquired immunity, but GIA is not•The breadth of IgG Fc-effector function is associated with protective immunitySummaryMalaria is a life-threatening disease of global health importance, particularly in sub-Saharan Africa.

Feb 8, 2023 | science.org | Scott Parker |Dennis Odera |Yang Xiao |Charlotte McDowall

InformationPublished In Science Translational MedicineVolume 15 | Issue 682February 2023CopyrightCopyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. This is an article distributed under the terms of the Science Journals Default License. Submission historyReceived: 6 December 2021Accepted: 17 January 2023PermissionsRequest permissions for this article. AcknowledgmentsWe thank O.

Feb 8, 2023 | science.org | Scott Parker |Dennis Odera |Yang Xiao |James Tuju

LATEST NEWS AbstractNatural killer (NK) cells are potent immune effectors that can be activated via antibody-mediated Fc receptor engagement. Using multiparameter flow cytometry, we found that NK cells degranulate and release IFN-γ upon stimulation with antibody-opsonized Plasmodium falciparum merozoites. Antibody-dependent NK (Ab-NK) activity was largely strain transcending and enhanced invasion inhibition into erythrocytes.

Feb 8, 2023 | science.org | Scott Parker |Dennis Odera |Yang Xiao |Pierre Emmanuel Noly

LATEST NEWS AbstractPreservation quality of donor hearts is a key determinant of transplant success. Preservation duration beyond 4 hours is associated with primary graft dysfunction (PGD). Given transport time constraints, geographical limitations exist for donor-recipient matching, leading to donor heart underutilization.

Feb 8, 2023 | science.org | Scott Parker |Dennis Odera |Yang Xiao |Kirill Batmanov

LATEST NEWS AbstractCurrent therapeutic strategies for treating nonalcoholic steatohepatitis (NASH) have failed to alleviate liver fibrosis, which is a devastating feature leading to hepatic dysfunction. Here, we integrated single-nucleus transcriptomics and epigenomics to characterize all major liver cell types during NASH development in mice and humans. The bifurcation of hepatocyte trajectory with NASH progression was conserved between mice and humans.