Kittikorn Wangriatisak

2 months ago | onlinelibrary.wiley.com | Charlotte de Vries |Wenqi Huang |Ravi Sharma |Kittikorn Wangriatisak

1 Introduction B cells are regarded as central in rheumatoid arthritis (RA), based on the efficacy of B-cell depleting therapies [1], and the hallmark presence of anti-citrullinated protein autoantibodies (ACPA) and rheumatoid factor (RF) in about two-thirds of RA patients. The autoantibody-positive group, referred to as seropositive, is characterized by a more severe disease course, indicating a pathogenic role for autoreactive B cells in RA.

Nov 26, 2024 | onlinelibrary.wiley.com | Kittikorn Wangriatisak |Charlotte de Vries |Ravi Sharma |Wenqi Huang

1 INTRODUCTION Systemic lupus erythematosus (SLE) is characterised by a broad spectrum of clinical manifestations, phenotypes and multiple abnormalities involving both the innate and acquired immune system.1-4 Autoantibodies, a hallmark of SLE, are produced by autoreactive plasma cells and plasmablasts (antibody-secreting cells; ASCs) generated through the later stages of B-cell development.