Klara Sonnie Hinrichsmeyer

Oct 18, 2023 | nature.com | Lisa Maria Riedmayr |Klara Sonnie Hinrichsmeyer |Michael Bartoschek |Christian Grimm |Jan Wijnholds |Stefanie Fenske | +1 more

AbstractLarge genes including several CRISPR-Cas modules like gene activators (CRISPRa) require dual adeno-associated viral (AAV) vectors for an efficient in vivo delivery and expression. Current dual AAV vector approaches have important limitations, e.g., low reconstitution efficiency, production of alien proteins, or low flexibility in split site selection. Here, we present a dual AAV vector technology based on reconstitution via mRNA trans-splicing (REVeRT).

Feb 7, 2023 | biorxiv.org | Lisa Maria Riedmayr |Klara Sonnie Hinrichsmeyer |Stefan Bernhard Thalhammer |Nina Karguth

Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.