Koichiro Haruwaka

Jan 4, 2024 | nature.com | Koichiro Haruwaka |Yanlu Ying |Anthony D. Umpierre |Min-Hee Yi |Vaclav Kremen |Tao Xie | +3 more

AbstractMicroglia are resident immune cells of the central nervous system and play key roles in brain homeostasis. During anesthesia, microglia increase their dynamic process surveillance and interact more closely with neurons. However, the functional significance of microglial process dynamics and neuronal interaction under anesthesia is largely unknown. Using in vivo two-photon imaging in mice, we show that microglia enhance neuronal activity after the cessation of isoflurane anesthesia.